EvidenceMD Logo
API v2.1
Purpose-Built for Healthcare

Developer API
OpenAI-Compatible Clinical Reasoning API

One API for all healthcare needs. Powered by advanced medical chain-of-thought reasoning, trained on peer-reviewed literature, and designed for evidence-based clinical decisions.

Stop using generic AI. EvidenceMD understands medicine.

AI Reasoning Benchmarks

How EvidenceMD compares to leading AI models on specialized reasoning tasks

Medical Reasoning
EvidenceMD AI API94%
GPT 5.283%
Claude 4.5 Opus76%
Google AI70%
Medical / Financial Reasoning
EvidenceMD AI API90%
GPT 5.280%
Claude 4.5 Opus75%
Google AI70%

See the Difference: Real Clinical Reasoning

EvidenceMD delivers structured, evidence-based responses with citations from peer-reviewed sources.

FeatureEvidenceMDOpenAIClaudeGemini
Citations & Sources
Peer-Reviewed Information
Clinical Reasoning
Biomedical Reasoning
EvidenceMD API Response
User Query:

"What's the treatment plan for aortic thoracic aneurysm 5.9cm in dialysis patient?"

EvidenceMD Response:

Executive Summary: Treatment Plan for 5.9 cm Thoracic Aortic Aneurysm in Dialysis Patient

The treatment plan requires a critical balance between the imminent risk of aortic rupture/dissection and the significantly elevated perioperative mortality associated with renal failure.

Immediate Recommendation:

A 5.9 cm TAA exceeds the standard intervention threshold of 5.5 cm established by the 2022 ACC/AHA Guidelines [1]. The management strategy must prioritize Thoracic Endovascular Aortic Repair (TEVAR) over open surgery if anatomically feasible.

1. Indication for Intervention:
  • Size Thresholds: Intervention at ≥5.5 cm per guidelines [1]
  • Critical Point: Sharp increase in dissection risk at 6.0 cm [26]
  • Dialysis Mortality: 30-day mortality ~17% for TEVAR [19]
2. Procedural Approach:
  • TEVAR preferred for descending TAA in high-risk patients [3]
  • Lower perioperative morbidity vs open repair [6]
  • 30-day survival 85.7% in dialysis patients [10]
Sources (8 peer-reviewed citations):

[1] ACC/AHA Guidelines 2022 - ahajournals.org

[3] SVS Guidelines - jvascsurg.org

[6] Ann Thorac Surg - annalsthoracicsurgery.org

[10] PMC Study - pmc.ncbi.nlm.nih.gov

[19] JTCVS - jtcvs.org

[26] JAMA Cardiology - jamanetwork.com

Real API response with inline citations and peer-reviewed sources

One API for All Healthcare Needs

Built for developers building the future of healthcare

Digital Health Apps

Patient education, symptom checkers, telehealth platforms

Pharma & Life Sciences

Drug discovery, clinical trials, medical writing

Medical Scribe

Clinical documentation, SOAP notes, EHR integration

Wellness & Longevity

Diet, nutrition, fitness, preventive health apps

API Documentation

OpenAI-compatible API. Drop-in replacement with medical superpowers.

Quick Start
Get started in under 2 minutes

1Get your API Key

Sign in with Google to get your API key from the dashboard.

2Make your first request

curl https://evidencemd.ai/api/v1/chat/completions \
  -H "Content-Type: application/json" \
  -H "x-api-key: YOUR_API_KEY" \
  -d '{
    "model": "evidencemd-fast",
    "messages": [
      {"role": "user", "content": "What is metformin?"}
    ],
    "stream": true
  }'

3Receive evidence-based response

Response includes inline citations [1], [2] with source URLs and a References section — all embedded in the content. Every response includes an x-request-id header for tracing.

Three models available:

evidencemd-fast— Quick answers, 1 credit
evidencemd-pro— Deep analysis, 2 credits
evidencemd-deep— 97% GPQA Diamond, 4 credits

Evidence-Based Clinical Reasoning

How EvidenceMD transforms clinical decision-making with AI-powered evidence synthesis

Chain-of-Thought Reasoning

Our model follows clinical reasoning patterns - from differential diagnosis to treatment planning, mimicking how physicians think through complex cases.

Real-Time Evidence Synthesis

Automatically retrieves and synthesizes evidence from peer-reviewed journals, clinical guidelines, and medical databases for every query.

Specialty-Aware Responses

Trained across 30+ medical specialties with understanding of specialty-specific guidelines, terminology, and treatment protocols.

Verifiable Citations

Every clinical claim is backed by inline citations from trusted sources - no hallucinations, no made-up references.

Enterprise Solutions

Need custom SLAs, dedicated instances, or volume pricing? Contact us for enterprise solutions.

Enterprise Ready
Custom SLAs Available

Ready to Build with Medical AI?

Join developers building the future of healthcare.

Developer API — OpenAI-Compatible Clinical Reasoning API | EvidenceMD