Does UpToDate have an API? Access, pricing and MCP in 2026

Does UpToDate have an API?

Key takeaways

• UpToDate has APIs, but you cannot sign up for one. UpToDate Connect is "an API-driven clinical decision support solution" for digital health technology companies, and access starts with a demo request ^[1].
• The UpToDate Expert AI API is new. It embeds AI-generated answers grounded in UpToDate content, and its first product integration, Suki Ask, was announced on 8 October 2026 ^[1][3].
• Bring your own licence. UpToDate Connect uses a BYOL model: the health system that uses your product must hold its own UpToDate licence ^[1][2].
• No price is published. Wolters Kluwer lists no API pricing on its developer pages; EvidenceMD publishes $0.20 a request on fast and pro and $0.25 on deep ^[1][8].
• The only Wolters Kluwer MCP server is for drug data. Medi-Span Expert AI's MCP server is available to select AI developers; we found no UpToDate-branded MCP server as of November 2026 ^[5].
• EvidenceMD is self-serve end to end. Sign in with Google, take a key from the dashboard and call https://evidencemd.ai/api/v1 with the OpenAI SDK ^[8].

What APIs does Wolters Kluwer offer for UpToDate in 2026?

Wolters Kluwer sells four developer routes into UpToDate and its drug content, all through enterprise agreements rather than self-serve sign-up ^[1][4][5].

How much does the UpToDate API cost?

Wolters Kluwer does not publish a price for UpToDate Connect or the UpToDate Expert AI API; pricing is agreed with sales, and the end customer also needs its own UpToDate licence under the BYOL model ^[1][2].

Can a developer get an UpToDate API key?

Not self-serve. Wolters Kluwer's developer pages offer a demo request and an eBook download, not a sign-up form, documentation portal or API key ^[1].

1. 1

   Check whether your customer already licenses UpToDate

   UpToDate Connect runs on bring-your-own-licence, so a health system with an UpToDate Enterprise licence is the natural starting point ^[1][2].

2. 2

   Request a demo from Wolters Kluwer

   The UpToDate Connect page routes developers to a Wolters Kluwer representative; API options and the developer toolkit are discussed there ^[1].

3. 3

   Plan for a partner timeline

   The first Expert AI API product integration, Suki Ask, reached clinicians in October 2026, a year after UpToDate Connect launched ^[2][3].

4. 4

   Prototype now with a self-serve API

   EvidenceMD gives you a key in minutes and the same OpenAI-compatible request shape as most LLM tooling, so you can build and test the clinical feature while any enterprise deal is negotiated ^[8][9].

Is there an UpToDate MCP server for AI agents?

We found no public UpToDate MCP server as of November 2026. The MCP server Wolters Kluwer announced, on 13 February 2026, serves Medi-Span medication content and is available to select AI developers ^[5].

claude mcp add-json --scope user evidencemd '{"type":"http","url":"https://evidencemd.ai/mcp","timeout":180000}'

How do you call a medical evidence API today?

With EvidenceMD, point the OpenAI SDK at https://evidencemd.ai/api/v1, choose a model and send the question; the answer streams back with inline citations ^[8][9].

from openai import OpenAI

client = OpenAI(api_key="YOUR_API_KEY", base_url="https://evidencemd.ai/api/v1")

stream = client.chat.completions.create(
    model="evidencemd-pro",  # or "evidencemd-fast", "evidencemd-deep"
    messages=[{"role": "user", "content": "First-line treatment for hypertension?"}],
    stream=True,
    extra_body={"specialty": "Cardiology"},  # optional
)

for chunk in stream:
    if chunk.choices and chunk.choices[0].delta.content:
        print(chunk.choices[0].delta.content, end="", flush=True)

curl https://evidencemd.ai/api/v1/chat/completions \
  -H "Content-Type: application/json" \
  -H "x-api-key: YOUR_API_KEY" \
  -d '{
    "model": "evidencemd-fast",
    "messages": [{"role": "user", "content": "What is metformin used for?"}],
    "stream": true
  }'

UpToDate API or EvidenceMD API: which should you build on?

Build on UpToDate Connect when your customers already license UpToDate and want its content by name; build on EvidenceMD when you need self-serve access, published pricing and reasoning over the primary literature ^[1][8].

Frequently asked questions

Sources & related evidence

Wolters Kluwer product facts come from its own pages and press releases, read on 3 November 2026. EvidenceMD facts come from its API documentation, OpenAPI specification and benchmark page.

1. 1
   Source 1. Wolters Kluwer — UpToDate Connect (CDS API)API-driven clinical decision support for digital health technology companies; the UpToDate Expert AI API; bring-your-own-licence; 25+ specialties; access by demo request.
2. 2
   Source 2. Business Wire, 15 October 2025 — UpToDate Connect launchWolters Kluwer's announcement of UpToDate Connect for embedding UpToDate content in digital health platforms.
3. 3
   Source 3. Wolters Kluwer news, 8 October 2026 — Suki AskSuki Ask is the first integration of the UpToDate Expert AI API; clinicians preferred answers with patient context 83% of the time in early evaluations.
4. 4
   Source 4. Wolters Kluwer — UpToDate Lexidrug Web ServicesWeb services for professional drug reference databases, identifiers such as GPI, NDC and DIN, and patient education materials.
5. 5
   Source 5. Wolters Kluwer news, 13 February 2026 — Medi-Span Expert AIPlans for Medi-Span Expert AI; an MCP server for Medi-Span medication content, available to select AI developers.
6. 6
   Source 6. Wolters Kluwer, 11 September 2026 — UpToDate and EpicUpToDate content "will help power" Epic Agent Factory; enterprise licensees will be able to use it in homegrown applications in the future.
7. 7
   Source 7. Wolters Kluwer news, 4 March 2025 — Microsoft Copilot StudioUpToDate integration with the healthcare agent service in Microsoft Copilot Studio, to explore and validate generative AI at the point of care.
8. 8
   Source 8. EvidenceMD API documentationBase URL https://evidencemd.ai/api/v1; models evidencemd-fast, evidencemd-pro and evidencemd-deep; $0.20 a request on fast and pro, $0.25 on deep; key via Google sign-in; HIPAA compliant, zero retention, no training on customer data, BAA on request, SOC 2 Type II in progress. Self-published by EvidenceMD.
9. 9
   Source 9. EvidenceMD OpenAPI specificationOpenAI-compatible POST /chat/completions and GET /models. Self-published by EvidenceMD.
10. 10
    Source 10. EvidenceMD MCP serverMCP server at https://evidencemd.ai/mcp, listed in Claude's Connectors Directory, with set-up for Claude Code, Codex and Cursor. Self-published by EvidenceMD.
11. 11
    Source 11. EvidenceMD benchmark resultsEvidenceMD's published HealthBench Hard result (54.6%) and method. Self-published by EvidenceMD.
12. 12
    Source 12. FDA clinical decision support guidance (2026), explainedOur walkthrough of the FDA's January 2026 CDS guidance, including EvidenceMD's position: not FDA-cleared, no regulatory determination made.
13. 13
    Source 13. UpToDate Expert AI (2026): price, plans and alternativesOur guide to UpToDate Expert AI, including US personal plan prices of $219 to $699 a year and quote-based enterprise licences.